ABOUT

R&D

GOTECH Antimicrobial develops graphene light-activated disinfection systems that can prevent healthcare associated infections.

The antimicrobial mechanism of action relies on a synergistic photothermal and photodynamic effect: GO converts light into heat and stimulates the overproduction of reactive oxygen species (ROS), leading to an increased membrane destabilisation, and consequently, bacterial death. 

Our patented technology relies on the irradiation of graphene with safe, low power, near-infrared light that kills 99% of the bacteria commonly found in infected catheters.

Publications

Most relevant publications

P.C. Henriques, A.T. Pereira, D. Bogas, J.R. Fernandes, A.M. Pinto, F.D. Magalhães, I.C. Gonçalves. Graphene films irradiated with safe low-power NIR-emitting diodes kill multidrug resistant bacteria. Carbon, 180, 10–21, 2021. https://doi.org/10.1016/j.carbon.2021.04.085

P.C. Henriques, A.T. Pereira, A.L. Pires, A.M. Pereira, F.D. Magalhães, I.C. Gonçalves. Graphene Surfaces Interaction with Proteins, Bacteria, Mammalian Cells and Blood Constituents: the Impact of Graphene Platelet Oxidation and Thickness. ACS Applied Materials and Interfaces, 12, 18, 21020–21035, 2020. https://doi.org/10.1021/acsami.9b21841 

P.C. Henriques, M. Ferreira, I.C. Gonçalves. Devices to fight catheter-related infections. Biomecánica, 29, 7-17, 2021. https://doi.org/10.5821/sibb.29.1.10917

I.C. Gonçalves, P.C. Henriques. Graphene: an ally for antibacterial biomaterials, in book New Trends in Smart Nanostructured Biomaterials in Health Sciences. Editors: G. Goncalves, P. Marques, J. Mano. Elsevier, 2022.

S.I. Amaral, R. Costa-Almeida, I.C. Gonçalves, F.D. Magalhães, A.M. Pinto. Carbon nanomaterials for phototherapy of cancer and microbial infections. Carbon, 190, 194-244, 2022. https://doi.org/10.1016/j.carbon.2021.12.084

Other related publications

D. Moura, A.T. Pereira, H.P. Ferreira, C.C. Barrias, F.D. Magalhães, H. Bergmeister, I.C. Gonçalves 6Poly(2-hydroxyethyl methacrylate) hydrogels containing graphene-based materials for blood-contacting applications: From soft inert to strong degradable material. Acta Biomaterialia 1:164, 253-268, 2023. https://doi.org/10.1016/j.actbio.2023.04.031

H.P. Ferreira, D. Moura, A.T. Pereira, P.C. Henriques, F.D. Magalhães, C.C. Barrias, I.C. Gonçalves. Using graphene-based materials for stiff and strong poly(ethylene glycol) hydrogels. International Journal of Molecular Sciences, 23(4), 2312, 2022. https://doi.org/10.3390/ijms23042312

A.T. Pereira, P.C Henriques, K.H. Schneider A.L. Pires, A.M. Pereira, M.C.L. Martins, F.D Magalhães, H. Bergmeister, I.C Gonçalves. Graphene-based materials: the key to a successful application of pHEMA as a blood contacting device. Biomaterials Science, 9(9) 3362–337, 2021 (IF 6.183). https://doi.org/10.1039/D0BM01699

A.T. Pereira, K.H. Schneider P.C. Henriques, C. Grasl, S.F. Melo, I.P. Fernandes, H. Kiss, M.C.L. Martins, H. Bergmeister I.C. Gonçalves. Graphene oxide coating improves mechanical and biological properties of decellularized arteries. ACS Applied Materials and Interfaces, 13, 28, 32662-32672, 2021 (IF 9.229). https://doi.org/10.1021/acsami.1c04028

S.F. Melo*, S.C. Neves*, A.T. Pereira, I. Borges, P.L. Granja, F.D. Magalhães, I.C. Gonçalves. Incorporation of graphene oxide into poly(ɛ-caprolactone) 3D printed fibrous scaffolds improves their antimicrobial properties. Materials Science & Engineering C 109, 110537, 2020. https://doi.org/10.1016/j.msec.2019.110537

I. Borges*, P.C. Henriques*, R.N. Gomes, M. Pestana, A.M. Pinto, F.D. Magalhães, I.C. Gonçalves. Exposure of Smaller and Oxidized Graphene on Polyurethane Surface Improves its Antimicrobial Performance. Nanomaterials, 10(2), 349, 2020. * equal contribution. https://doi.org/10.3390/nano10020349

A.T. Pereira, P.C. Henriques, P. Costa, M.C.L. Martins, F.D. Magalhães, I.C. Gonçalves. Graphene oxide-reinforced poly(2-hydroxyethyl methacrylate) hydrogels with extreme stiffness and high-strength. Composites Science and Technology, 184, 107819, 2019 (IF 6.309). https://doi.org/10.1016/j.compscitech.2019.107819

P.C. Henriques, I. Borges, A.M. Pinto, F.D. Magalhães, I.C. Gonçalves. Fabrication and antimicrobial performance of surfaces integrating graphene-based materials. Carbon 132, 709-732, 2018. https://doi.org/10.1016/j.carbon.2018.02.027

R.N. Gomes, I. Borges, A.T. Pereira, A.F. Maia, M. Pestana, F.D. Magalhães, A.M. Pinto, I.C. Gonçalves. Antimicrobial graphene nanoplatelets coatings for silicone catheters. Carbon 139, 635-647, 2018. https://doi.org/10.1016/j.carbon.2018.06.044

Our academic, industrial, technology transfer, and medical device regulatory expertise make us the perfect partner for your biomaterials and medical devices related R&D projects. We can collaborate with you as an R&D partner, or as a service provider/consultant. 

GOTECH’s strategic collaboration with i3S provides access to vanguard scientific knowhow, human resources, facilities, and equipment. 

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